An Online Respiratory Quotient-Feedback Strategy of Feeding Yeast Extract for Efficient Arachidonic Acid Production by Mortierella alpina

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An Online Respiratory Quotient-Feedback Strategy of Feeding Yeast Extract for Efficient Arachidonic Acid Production by Mortierella alpina

Mortierella alpina (M. alpina) is well known for arachidonic acid (ARA) production. However, low efficiency and unstableness are long existed problems for industrial production of ARA by M. alpina due to the lack of online regulations. The aim of the present work is to develop an online-regulation strategy for efficient and stable ARA production in industry. The strategy was developed in 50 L f...

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An efficient multi-stage fermentation strategy for the production of microbial oil rich in arachidonic acid in Mortierella alpina

BACKGROUND Fungal morphology and aeration play a significant role in the growth process of Mortierella alpina. The production of microbial oil rich in arachidonic acid (ARA) in M. alpina was enhanced by using a multi-stage fermentation strategy which combined fed-batch culture with precise control of aeration and agitation rates at proper times. RESULTS The fermentation period was divided int...

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Statistical Optimization of Arachidonic Acid Production by Mortierella alpina CBS 754.68 in Submerged Fermentation

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Statistical optimization of arachidonic acid production by Mortierella alpina CBS 754.68 in submerged fermentation

Arachidonic acid is an essential fatty acid in human nutrition. In the present study, production of arachidonic acid by Mortierella alpina CBS 754.68 was evaluated in submerged fermentation. The fermentation variables were selected in accordance with the PlackettBurman (PB) design and further optimized via response surface methodology (RSM). Five significant variables, namely glucose, yeast ext...

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ژورنال

عنوان ژورنال: Frontiers in Bioengineering and Biotechnology

سال: 2018

ISSN: 2296-4185

DOI: 10.3389/fbioe.2017.00083